膳食补充剂在我们每个时代都是必不可少的。它们帮助身体应对压力,预防多种疾病,并有助于摆脱各种病症。胶束维生素是提高生活水平的高性能产品。

由于用于创造它们的特殊技术,这些产品是独一无二的。主要是胶束技术。其原因在于生成了生物仿制药胶束,这种胶束多次增加了人体对营养素的吸收。没有它们,我们只能从食物或膳食补充剂中吸收10-15%的维生素和微量元素,并在胶束的帮助下 - 100%。以下是该产品的优点:

唯一性。 补充剂是根据原始配方创造的。

生物利用率。 制剂含有天然物质,使用胶束很容易被人体吸收。

高品质。 我们保证所有产品都是可靠的和高质量的。它们只会对身体有益。

辅酶Q10 +α硫辛酸是 一种推荐用于高血压,慢性疲劳综合症,心力衰竭,牙周病患者,以及吸烟者和积极生活方式的人士。

Α -硫辛酸有助于有效地将碳水化合物转化为能量,也是一种极好的抗氧化剂。

辅酶Q10 使新陈代谢正常化,防止细胞过早衰老并增强免疫系统。它适用于糖尿病。

CURCUMIN是一种可以增强免疫系统,恢复体力,提高效率的药物。姜黄素 - 主要成分 - 从天然姜黄中提取。它可以避免感冒和流感,即使在流行期间也不会生病。此外,它可缓解压力和抑郁,有助于病后恢复。

姜黄素被推荐用于预防癌症和抗癌的人。该产品增强了身体对抗癌细胞的能力。该物质有助于避免结核病并迅速从这种疾病中恢复。它可以防止胆囊和肝脏中结石的形成,有助于减轻体重,改善胶原蛋白的产生。建议任何想要延长寿命,保护青少年,从现有疾病中恢复并防止出现新疾病的人接受它。

辅酶Q10。推荐作为辅酶Q10的额外来源的产品。该物质具有许多有益的特性。细胞内的酶的作用是必要的,充当抗氧化剂,中和自由基。支持老年人器官的正常功能,减缓衰老,增加抗病能力。

Q10对心肌功能减弱的人有用,可以避免高血压,防止血栓形成,并有助于心律失常。它可延长乳腺癌或前列腺癌的生命,减少牙龈出血,减缓阿尔茨海默病的发展。

ADEK是一种维生素复合物,含有维生素 A,E,D,K。它们可以改善新陈代谢,使皮肤更好,强化骨骼,牙齿,头发和指甲,有助于增加神经系统的耐力,加强肌肉。它们可改善血液循环,确保其正常凝血,使男性和女性生殖系统的工作正常化。维生素有助于哮喘和糖尿病,清除凝块中的血管,防止骨质疏松症,促进适当的蛋白质合成。该药可改善血液凝固,用于伤及伤口,有助于治疗消化性溃疡

Micellation - Encapsulation at Nano-Level

A transport system according to Nature's principle as a prerequisite for the absorption and digestion of lipids

Prof. Dr. Elstner

Technical University Munich

Prof. Dr. Ing. Kulozik

Technical University Munich

Dr. Weiser

AQUANOVA AG

Prof. Dr. Ing. Weiss

University of Hohenheim

Prof. Dr. J. Kreuter

Goethe University Frankfurt

Prof. Dr. K.-D. Jany

Technical University Hamburg Harburg

Prof. Dr. H. Rehage

Technical University Dortmund

Prof. Dr. Ing. Back

Technical University Munich

Prof. Dr. Biesalski

University of Hohenheim

Prof. Dr. Weber

Beuth University Berlin

Prof. Dr. J. B. Dressman

Goethe University Frankfurt

Physiological mixed micelles - fundamental for lipid resorption

The digestion and absorption of nutritional fats (principally triglycerides) in human beings is a process which is characterized by a number of different steps. The first step in fat digestion is the formation of an emulsion of the disperse lipids. In the stomach the hydrolysis (lipolysis) of the triglycerides in free fatty acids, monoglycerides and glycerol then follows through gastric lipases. About 20 - 30% of the complete lipolysis of nutritional fats occurs in the stomach. The lipolysis is terminated in the small intestine (duodenum and upper part of the jejunum) by the influence of the pancreatic lipase and colipase. The lipolysis products which are insoluble in water are released in the form of water-soluble mixed micelles to the cells of the small intestine for absorption. The water-soluble mixed micelles are molecular aggregates of fatty acids, monoglycerides, cholesterols, phospholipids, fat-soluble vitamins, antioxidants and conjugated bile acids. They are formed when the concentration of the conjugated bile acids is higher than their "critical micelle formation concentration" (CMC). The physiological micelle facilitates the transport and the release of the water-insoluble products of the lipolysis and of other fat-soluble molecules via the so-called "unstirred water layer", which is located on the luminal cell membrane of the small intestine, to the point of resorption.

Limiting factors in the efficient formation of a physiological micelle are primarily the availability of conjugated bile acids. If the duodenal concentration of the conjugated bile acids is below their CMC, substantial disturbance to the micellation occurs. Reduced availability of pancreatic lipases, variations in the intraduodenal pH value and a reduced supply of bile liquid can prevent the optimum physiological micellation. Under some circumstances this may lead to essential fat-soluble vitamins and antioxidants being poorly ingested or not ingested at all.

The product micelle (see below) is not subject to these physiological variations and can thus be regarded as a natural "smart transport and delivery system" or one that is analogous to the natural principle. Micellar structures on the nanoscale are found, for example, in foodstuffs such as milk (casein submicelle with a diameter between 10 - 20 nm) or the hen's egg (LDL and HDL cholesterol micelle with a diameter between 20 - 60 nm).

A remarkable property of the micelle is the capability of encapsulating non-polar lipids, antioxidants and fatsoluble vitamins in order to transport them in this manner in an aqueous medium (e.g. in the gastrointestinal fluid). Thus, water-insoluble organic compounds can be rendered water-soluble with the aid of micelles.

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Micellar structures - all-pervasive principle of nature

Micelles are spherical particles with a diameter of 10 - 200 nanometers. They are found in:

  1. natural foodstuffs, such as milk,
  2. natural foodstuffs, such as the hen's egg,
  3. the natural, human, physiological mixed micelle,
  4. the product micelle.
1 2 3 4
Milk: Casein Micelle and Casein submicelle Hen's egg: LDL micelle Human being: Physiological micelle Solubilisate: Product micelle (e.g.. Vitamin E)

D = 50 – 250 nm / D = 10 – 20 nm D = 20 – 60 nm D = ≤ 50 nm D ≈ 30 nm
Prof. Dr.-Ing. U. Kulozik, TU München / Schmidt, 1980; Walstra und Jennes, 1984; Fox, 1989 Prof. Dr.-Ing. U. Kulozik, TU München Dr. Evelyn Back, Prof. H. K. Biesalski, (Taschenatlas der Ernährung, Uni Hohenheim) AQUANOVA, TU Darmstack

The product micelle - implementing the natural principle in products

The structure of the product micelle, with a size of appr. 30 nm, is similar to the structure of the naturally formed physiological mixed micelle containing water-insoluble compounds in its core which is enclosed by ambiphilic molecules. The chemical or molecular structures of the micellized ingredients are fully retained in the product micelle. The product micelle is chemically and mechanically stable and is also stable in gastric acid. It releases the ("transported") fat-soluble compound enclosed in it chemically unmodified to the luminal cell membranes of the small intestine for absorption. That the transported fat-soluble compounds (vitamins & antioxidants) remain completely unchanged in the product micelle is shown by determining the content in the solubilisate itself (HPLC analysis) and the concentration of these unchanged compounds. The higher bioavailability, which is obtained by the product micellation, is based on the independence of this transport system from the limiting parameters in the formation of the physiological mixed micelle. It is important to appreciate the product micelle's character as an "encapsulation and transport medium". This must not be confused with "nanoparticles" which are often spoken about in nanotechnology and which, for example, are used in sun lotions or technical applications such as surface sealing. In contrast to these substances, the substances encapsulated in the product micelle are a natural object of metabolism or physiological processing in the human body. In addition, no new types of substances or nanoparticles are used in the formation of the product micelle.

Conclusion

Nanostructures in the form of micelles have great potential in improving the efficiency of the transport, release and absorption of nutraceuticals and bioactive compounds in functional foods (smart transport and delivery system). In principle the micelle can increase the controlled release and the bioavailability of the enclosed bioactive compounds.

Due to the solubilization of lipophilic raw materials and active ingredients, such as vitamin E, ß-carotene or coenzyme Q10, so-called product micelles can be produced, which are similar in the size, shape and functionality to the natural, physiological micelle. In this respect the molecules of the micellated (encapsulated) raw materials and active ingredients are not modified. Since the natural micelle formation, hence Nature, is mimicked by the solubilization, the requirement of a toxicological reassessment of a solubilisate is in no way required. The components of the product micelle have been assessed individually and do not change their toxicological profile due to the micellation.

This document has been created with the involvement of the CEO from AQUANOVA AG, Darmstadt Dipl.-Ing. Dariush Behnam for the purpose of differentiation nanoscaled colloidal carrier systems to anorganic nanoparticles (NEM).

Research Article Molecular Nutrition & Food Research 2014, 58, 516–527

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C. Schiborr, et al., The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes, Molecular Nutrition & Food Research 2014, in press

Overall, based on all data generated, clear differences in bioavailability between the formulations have been found, although, in contrast to other studies, standardized conditions for all formulations, whether fat or water soluble, were guaranteed, resulting in equal absorption opportunities for all of them.

Looking at the AUC, the major indicator for bioavailability, NovaSOL Q 3% (F) is superior followed by NovaSOL Q 5% (A) and CoQ-Gel (D). The results show clear superiority of the water soluble solutions over oil based suspensions, i.e. CoQsol (C) and Nature Made CoQ (E) as well as over straight CoQ 10 (B)

Looking at long time supplementation and the rate at which the steady state is reached, NovaSOL Q 5% (A) is clearly superior to all other formulations.

  • Straight CoQ10 (hard gels) has the slowest absorption and the lowest bioavailability (BV) although given with fat
  • NovaSOL Q has overall the best BV of all preparations
  • AUC0-4h ratios between formulations and straight CoQ10:
    • Straight CoQ10 (B): 1.0
    • CoQsol (C): 1.6
    • Nature Made (E): 1.7
    • CoQ-Gel (D): 3.1
    • NovaSOL Q 5% (A): 3.3
    • NovaSOL Q 3% (F): 4.0
  • NovaSOL Q 5% shows the fastest increase in the blood and reaches the steady state first (7days) followed by E = F > B = D > C
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NovaSOL®技术已通过GRAS和FDA的安全认证。

NovaSOL®的生产和产品符合最严格的行业标准ISO 22000,GMP-Pharma,Kosher,HALAL和HACCP。Novasol不含过敏原和转基因生物。